Linking m 6 A to Wnt signaling
نویسندگان
چکیده
منابع مشابه
Linking Colorectal Cancer to Wnt Signaling
emerged shortly after this, when the Wnt pathway was *MRC Laboratory of Molecular Biology discovered by genetic analysis in Drosophila. Specific Hills Road mutant phenotypes led to the identification of critical Cambridge CB2 2QH Wnt signaling components, while epistasis experiments United Kingdom determined the functional order of these components ‡Department of Immunology and in the pathway. ...
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Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...
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The loss of the SOST gene product sclerostin leads to sclerosteosis characterized by high bone mass. In this report, we found that sclerostin could antagonize canonical Wnt signaling in human embryonic kidney A293T cells and mouse osteoblastic MC3T3 cells. This sclerostin-mediated antagonism could be reversed by overexpression of Wnt co-receptor low density lipoprotein receptor-related protein ...
متن کاملLinking Frizzled and Wnt signaling in Drosophila development.
Drosophila Frizzled-2 (Dfz2) has been identified as a putative fly Wingless (Wg) receptor. Although Dfz2 shows significant homology with Fz, a protein that operates in the mechanisms that establish planar polarity in Drosophila epithelia, any clear evidence for an involvement by Fz in a Wnt signaling pathway has hitherto been absent. Here we describe the planar polarity phenotypes of loss-of-fu...
متن کاملLinking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom).
Epigenetic modifications of chromatin play an important role in the regulation of gene expression. KMT4/Dot1 is a conserved histone methyltransferase capable of methylating chromatin on Lys79 of histone H3 (H3K79). Here we report the identification of a multisubunit Dot1 complex (DotCom), which includes several of the mixed lineage leukemia (MLL) partners in leukemia such as ENL, AF9/MLLT3, AF1...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2020
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.202050097